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The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene Symbol
AXL
UFO
Protein Target
Axl
Target Sub-Family
TK
UniProt Number
P30530
UniProt Summary
FUNCTION: SwissProt: P30530 # May function as a signal transducer between specific cell types of mesodermal origin. SIZE: 887 amino acids; 97437 Da SUBUNIT: Heterodimer and heterotetramer with GAS6. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. DISEASE:SwissProt: P30530 # Has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia. SIMILARITY: SwissProt: P30530 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. & Contains 2 fibronectin type-III domains. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
Product Usage Statements
Quality Assurance
Routinely evaluated by for use as a substrate in protein kinase assay.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
