The store will not work correctly when cookies are disabled.
We use cookies to make your experience better.To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Millipore Milli-Mark Anti-Nanog-Alexa Fluor 488 Antibody, Nt
Millipore Milli-Mark Anti-Nanog-Alexa Fluor 488 Antibody, Nt
List Price$449.12Your Price$449.12
Millipore Milli-Mark Anti-Nanog-Alexa Fluor 488 Antibody, N-Terminus Is An Antibody Against Nanog-Alexa Fluor 488 For Use In Fc. - Mill (Additional S&H or Hazmat Fees May Apply)
Milli-Mark™ Anti-Nanog-Alexa Fluor 488 Antibody, NT
Alternate Names
Homeobox transcription factor Nanog
Nanog homeobox
Background Information
NANOG is a gene expressed in embryonic stem cells (ESCs) and is thought to be a key factor in maintaining pluripotency. NANOG thought to function in concert with other factors such as POU5F1 and SOX2 to establish ESC identity. These cells offer an important area of study because of their ability to maintain pluripotency, i.e., these cells have the ability to become virtually any cell of any of the three germ layers (endoderm, ectoderm, mesoderm). NANOG may be useful in the immunohistochemical diagnosis of tumors. NANOG is expressed in germ cells of the fetus and in some germ cell tumors of the gonads and central nervous system (CNS).
Product Information
Format
AlexaFluor®488
Control
2102 Ep cells
Presentation
Purified rabbit polyclonal IgG conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA
Quality Level
MQ100
Applications
Application
Milli-Mark Anti-Nanog-Alexa Fluor 488 Antibody, N-terminus is an antibody against Nanog-Alexa Fluor 488 for use in FC.
Key Applications
Flow Cytometry
Biological Information
Immunogen
Linear peptide from mouse Nanog.
Epitope
N-terminus
Host
Rabbit
Specificity
Antibody recognizes NANOG.
Isotype
IgG
Species Reactivity
Human
Mouse
Rat
Species Reactivity Note
Tested and passed on Human. Predicted to react with Mouse, Rat based on 100% sequence homology.
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NP_079141
Gene Symbol
FLJ12581
FLJ40451
hNanog
Purification Method
Antigen Affinity Purified
UniProt Number
Q9H9S0
UniProt Summary
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor, when overexpressed, promotes cells to enter into S phase and proliferation.
Molecular Weight
34 kDa Calculated
Product Usage Statements
Quality Assurance
Evaluated by flow cytometry using 2102 Ep cells
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
