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Millipore Full Length, Recombinant Human Src. N-Terminal C-Myc, 6his-Tagged. For Use In Enzyme Assays. Functions As A Substrate In Ubiquitination Assays. - Mill (Additional S&H or Hazmat Fees May Apply)
N-terminal cMyc and GST-tagged, recombinant human IKKγ full length, expressed by baculovirus in Sf21 insect cells.
Alternate Names
Proto-oncogene c-Src
pp60c-src
SRC1
Background Information
Src is a ubiquitously expressed, non-receptor tyrosine kinase that plays a pivotal role in numerous cellular processes such as proliferation, migration, and transformation. Due to its critical function in regulating signal transduction pathways, Src activity is tightly controlled through reversible phosphorylation and dephosphorylation events and down-regulation by ubiquitin-dependent degradation. Dysfunction of Src, through overexpression or increased activation has profound effects on basic cellular functions. Elevated Src expression and/or activation is evident across a wide range of solid tumour types and has been strongly implicated in the development, maintenance, progression, and metastatic spread of several human cancers, such as prostate, lung, breast, and colorectal cancer.
Product Information
Quality Level
MQ100
Applications
Application
Full length, recombinant human Src. N-terminal c-Myc, 6His-tagged. For use in Enzyme Assays. Functions as a substrate in ubiquitination assays.
Key Applications
Enzyme Assays
Biological Information
Specific Activity
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Cascade Component
Substrate
Entrez Gene Number
NM_198291
Purification Method
Purified using immobilized metal affinity chromatography.
Product Usage Statements
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
