The store will not work correctly when cookies are disabled.
We use cookies to make your experience better.To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service.
Description
Catalogue Number
14-939
Trade Name
Upstate
Description
ErbB2, active
Overview
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization
Product Information
Presentation
Protein in 50mM Tris/HCl pH7.5, 150mM NaCl, 0.5mM EDTA, 0.01% CHAPS, 50% glycerol, 2mM DTT. Frozen solution.
Quality Level
MQ100
Applications
Key Applications
Kinase Assay
Biological Information
Specific Activity
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
NM_004448,G778D
Gene Symbol
ERBB2
HER2
NGL
NEU
HER-2
TKR1
MLN19
Protein Target
ErbB2
Purification Method
Purified using immobilized metal affinity chromatography.
Target Sub-Family
TK
UniProt Number
P046263
Molecular Weight
69 kDa
Product Usage Statements
Quality Assurance
Routinely evaluated by phosphorylation of poly(Glu, Tyr) (4:1)
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
6 months at -70°C
Packaging Information
Material Size
10 µg
Material Package
Also available in 250μg size as catalog # 14-939M and in bulk as catalog # 14-939-K.
