Cell Signaling Mmp-3 (D7f5b) Rabbit mAb

Name: Cell Signaling Mmp-3 (D7f5b) Rabbit mAb
SKU: CSIG-14351S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Mmp-3 (D7f5b) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-14351S

MFG.PART: 14351S

UNSPSC: 41116113

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H R
Sensitivity	Endogenous
Molecular Weight (kDa)	60
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	MMP-3 (D7F5B) Rabbit mAb recognizes endogenous levels of total MMP-3 protein.
Species Reactivity	Human, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser417 of human MMP-3 protein.
Background	The matrix metalloproteinases (MMPs) are a family of proteases that target many extracellular proteins including other proteases, growth factors, cell surface receptors, and adhesion molecules (1). Among the family members, MMP-2, MMP-3, MMP-7, and MMP-9 have been characterized as important factors for normal tissue remodeling during embryonic development, wound healing, tumor invasion, angiogenesis, carcinogenesis, and apoptosis (2-4). Research studies have shown that MMP activity correlates with cancer development (2). One mechanism of MMP regulation is transcriptional (5). Once synthesized, MMP exists as a latent proenzyme. Maximum MMP activity requires proteolytic cleavage to generate active MMPs by releasing the inhibitory propeptide domain from the full-length protein (5).

Specifications