Cell Signaling Erap1 (E6x1p) Rabbit mAb

Name: Cell Signaling Erap1 (E6x1p) Rabbit mAb
SKU: CSIG-99979S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Erap1 (E6x1p) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-99979S

MFG.PART: 99979S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	100
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	ERAP1 (E6X1P) Rabbit mAb recognizes endogenous levels of total ERAP1 protein. This antibody does not cross-react with ERAP2 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly840 of human ERAP1 protein.
Background	Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an IFN-γ inducible peptidase that is inserted into the endoplasmic reticulum (ER) membrane as a type II transmembrane protein (1). Research studies have shown that ERAP1 influences the adaptive branch of the immune system by facilitating the maturation of peptide fragments that are loaded onto MHC class I alleles, which are then presented for recognition by T lymphocytes (2,3). Defects in ERAP1 are associated with human disease. Multiple single nucleotide polymorphisms have been identified within ERAP1, which alter the enzymatic activity of the protein product and, in conjunction with HLA-B27, confer susceptibility to ankylosing spondylitis, an inflammatory disease that affects joints (4,5).

Specifications