Cell Signaling Ncam-L1 (D5d3k) Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Ncam-L1 (D5d3k) Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-97986SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Ncam-L1 (D5d3k) Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-97986SF

MFG.PART: 97986SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	220
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA, and Azide Free. For standard formulation of this product see product #90269.
Specificity/Sensitivity	NCAM-L1 (D5D3K) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total NCAM-L1/L1CAM protein.
Species Reactivity	Human, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human NCAM-L1/L1CAM protein.
Background	Neural cell adhesion molecule L1 (NCAM-L1/L1CAM) is a single pass transmembrane glycoprotein member of the immunoglobulin superfamily, containing six amino-terminal extracellular Ig-like domains followed by five fibronectin type-III domains (1). NCAM-L1 is mainly expressed in the brain, and plays an important role in the developing nervous system, with involvement in neurite fasciculation and outgrowth, myelination, neuronal migration, and neuronal cell adhesion (2). Mutations in the NCAM-L1 gene cause varying degrees of neurological disease including X-linked hydrocephalus, MASA syndrome, spastic paraplegia type 1, and X-linked corpus callosum agenesis, together known as L1 syndrome (3). Apart from the nervous system, NCAM-L1 is overexpressed in many cancers and supports a poor prognosis by facilitating aggressive tumor growth, metastasis, and chemoresistance (4,5).

Specifications