Cell Signaling Cleaved Caspase-8 (Asp387) (D5B2) XP ® Rabbit mAb (BSA and Azide Free) 100 ug

Name: Cell Signaling Cleaved Caspase-8 (Asp387) (D5B2) XP ® Rabbit mAb (BSA and Azide Free) 100 ug
SKU: CSIG-97756SF
Price: 884.76 USD

List Price $884.76 Your Price $884.76

Cell Signaling Cleaved Caspase-8 (Asp387) (D5B2) XP ® Rabbit mAb (BSA and Azide Free) 100 ug - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-97756SF

MFG.PART: 97756SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	M
Sensitivity	Endogenous
Molecular Weight (kDa)	18, 43
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #8592
Specificity/Sensitivity	Cleaved Caspase-8 (Asp387) (D5B2) XP® Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of mouse caspase-8 only when cleaved at Asp387. In addition to the p18 subunit, this antibody also detects cleavage products containing the pro-domain with the p18 subunit (p43).
Species Reactivity	Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp387 of mouse caspase-8 protein.
Background	Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10 (1-3). Activated caspase-8 cleaves and activates downstream effector caspases such as caspase-1, -3, -6, and -7. Caspase-3 ultimately elicits the morphological hallmarks of apoptosis, including DNA fragmentation and cell shrinkage.

Specifications