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Cell Signaling Padi2 (E3p8z) Rabbit mAb
List Price
$342.39
Your Price
$342.39
Cell Signaling Padi2 (E3p8z) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-97647S
MFG.PART:
97647S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 76 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:50} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | PADI2 (E3P8Z) Rabbit mAb recognizes endogenous levels of total PADI2 protein. |
| Species Reactivity | Human |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly375 of human PADI2 protein. |
| Background | Peptidyl arginine deiminase (PAD) proteins are a family of Ca2+-dependent enzymes that catalyze the post-translational conversion of arginine to citrulline. There are currently five known PAD isozymes in humans, referred to as PADI1-4 and PADI6 (1). Among these isozymes, peptidyl arginine deiminase type 2 (PADI2) is the most widely expressed, being found in skeletal muscle, brain, colon, breast, macrophages, spleen, and spinal cord tissue, among others (1,2). In normal mouse development, PADI2 expression levels are elevated from 18 days to 2 months of age, and gradually decrease from 3 months onward (3). Some of the most well studied PADI2 substrates include vimentin, actin, myelin basic protein (MBP), glial fibrillary acidic protein (GFAP), and histones (4). PADI2-mediated citrullination has been shown to be involved in neurodegeneration and inflammatory response-associated diseases such as multiple sclerosis (MS), Alzheimer’s disease (AD), psoriasis, and rheumatoid arthritis (5). Excessive PAD-mediated deimination of MBP is believed to be a major contributor to MS disease progression, while elevated levels of citrullinated GFAP and vimentin proteins have been found in the brains of AD patients (2,4). PADI2 has also been found to play a role in the progression of several types of cancers, including colorectal, breast, and prostate (5-7). |
| SKU | CSIG-97647S |
|---|---|
| Featured | No |
| Supplier Part Number | 97647S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |