Cell Signaling Cd180/Rp105 Antibody

Name: Cell Signaling Cd180/Rp105 Antibody
SKU: CSIG-97597S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Cd180/Rp105 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-97597S

MFG.PART: 97597S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	98
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	CD180/RP105 Antibody recognizes endogenous levels of total CD180/RP105 protein.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp483 of human CD180/RP105 protein. Antibodies are purified by peptide affinity chromatography.
Background	CD180/RP105 is a type-I transmembrane glycoprotein that is restricted to expression in mature B-cells. Research studies have shown that CD180 engages signaling cascades in mature B-cells that drive cell proliferation (1-3). Indeed, CD180 functions with TLR4 as an LPS receptor on B-cells and, upon binding LPS, transmits proliferation and survival signals that require the Vav family of guanine nucleotide exchange factors (4-6).

Specifications