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Cell Signaling Abca1 (E7x5g) Rabbit mAb
List Price
$342.39
Your Price
$342.39
Cell Signaling Abca1 (E7x5g) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-96292S
MFG.PART:
96292S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H M R |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 254 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:50} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | ABCA1 (E7X5G) Rabbit mAb recognizes endogenous levels of total ABCA1 protein. |
| Species Reactivity | Human, Mouse, Rat |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser1262 of human ABCA1 protein. |
| Background | ATP-binding cassette (ABC) proteins are membrane-residing transporters that transport substrates across the membrane in an ATP-dependent manner. ABC substrates subject to active transport across the membrane include ions, amino acids, lipids, and sterols (1). ATP-Binding cassette sub-family A member 1 (ABCA1) is a member of the ABC family and functions to regulate phospholipid and cholesterol homeostasis. ABCA1, like most ABC transporters, contains two transmembrane domain bundles composed of six membrane-spanning helices and two nucleotide-binding domains. ABCA1 and its closest homolog, ABCA7, are 12A class members of ABCs, and both proteins function to transport cholesterol and phospholipids in an apolipoprotein A (apoA)-dependent manner (2,3). ABCA1 is expressed in a variety of tissues (4). Loss of function mutations in the human ABCA1 gene are linked to Tangier disease, a disorder characterized by high density lipoprotein (HDL) deficiency and cholesterol ester buildup in macrophages, as well as increased risk of atherosclerosis, consistent with ABCA1s function in maintaining cholesterol homeostasis and HDL formation (5-8). ABCA1 is also a candidate risk gene for late onset Alzheimers disease (LOAD), a neurodegenerative disease that is also linked to altered cholesterol transport and metabolism (9). ABCA1 dysfunction may contribute directly to Alzheimers disease (AD) pathogenesis by accelerating amyloid-β (Aβ) production, which is one of the pathological hallmarks of AD (9). |
| SKU | CSIG-96292S |
|---|---|
| Featured | No |
| Supplier Part Number | 96292S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |