Cell Signaling Celf1 (E8q4g) Rabbit mAb

Name: Cell Signaling Celf1 (E8q4g) Rabbit mAb
SKU: CSIG-95084S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Celf1 (E8q4g) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-95084S

MFG.PART: 95084S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	58
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	CELF1 (E8Q4G) Rabbit mAb recognizes endogenous levels of total CELF1 protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro252 of human CELF1 protein.
Background	CELF1, also known as CUG-BP1, is a member of the CUG-BP, Elav-like family (CELF), which can bind enhancers to direct alternate splicing (1). CELF1 is widely expressed, can bind triple CUG repeat sequences, and was initially shown to play a role in alternative translation of C/EBP isoforms. (2-4). CELF1 plays an important role in the pathogenesis of myotonic dystrophy, a disease categorized by expansion of CTG repeats in the myotonia protein kinase gene (DMPK). This kinase is capable of phosphorylating CELF1, which can regulate its localization and affect mRNA processing and transport (2,3). In addition, CELF1 has also been shown to play roles in various cancer types (5-7).

Specifications