Cell Signaling Ifit2 Antibody

Name: Cell Signaling Ifit2 Antibody
SKU: CSIG-92633S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Ifit2 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-92633S

MFG.PART: 92633S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	55
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	IFIT2 Antibody recognizes endogenous levels of total IFIT2 protein.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human IFIT2 protein. Antibodies are purified by peptide affinity chromatography.
Background	IFIT2 (Interferon-induced protein with tetratricopeptide repeats 2, ISG54) belongs to the IFIT family of proteins, which consists of four members in humans (IFIT1, IFIT2, IFIT3, and IFIT5) and three members in mice (IFIT1, IFIT2, and IFIT3) (1). IFIT2 expression is transiently induced by exposure to interferons, double-stranded RNA, or viruses (2). IFIT2 has been shown to inhibit translation by binding to the eukaryotic initiation factor 3 (eIF3) (2). In addition, IFIT2 forms a multiprotein complex with the related proteins IFIT1 and IFIT3, which stimulates cell death via a mitochondrial pathway and prevents viral replication (3,4).

Specifications