Cell Signaling Tasor (E6m2y) Rabbit mAb

Name: Cell Signaling Tasor (E6m2y) Rabbit mAb
SKU: CSIG-92278S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Tasor (E6m2y) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-92278S

MFG.PART: 92278S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	195, 210, 250
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	TASOR (E6M2Y) Rabbit mAb recognizes endogenous levels of total TASOR protein. This antibody detects 75 and 78 kDa bands of unknown origin.
Species Reactivity	Human, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu844 of human TASOR protein.
Background	TASOR (also known as FAM208A or RAP140), along with MPP8, periphilin, and MORC2, comprise members of the human silencing hub (HUSH) complex, which is recruited to sites of H3K9me3 and helps target SETDB1 to maintain transcriptional repression (1,2). In addition to functioning at genomic sites, the HUSH complex also cooperates with TRIM28 to silence LINE-1 elements (3,4). TASOR has been shown to play a critical role in early embryonic development (5,6). Additionally, TASOR cooperates with the RNA deadenylase scaffold protein CNOT1 to repress HIV expression (7).

Specifications