Cell Signaling Cd8alpha (C8/144b) Mouse mAb (Ihc Specific) (Bsa And Azide Free)

Name: Cell Signaling Cd8alpha (C8/144b) Mouse mAb (Ihc Specific) (Bsa And Azide Free)
SKU: CSIG-90257SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Cd8alpha (C8/144b) Mouse mAb (Ihc Specific) (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-90257SF

MFG.PART: 90257SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Mouse IgG1
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #70306.
Specificity/Sensitivity	CD8α (C8/144B) Mouse mAb (BSA and Azide Free) recognizes endogenous levels of total CD8 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CD8 protein.
Background	Cluster of Differentiation 8 (CD8) is a disulphide-linked heterodimer consisting of the unrelated α and β subunits. Each subunit is a glycoprotein composed of a single extracellular Ig-like domain, a polypeptide linker, a transmembrane part and a short cytoplasmic tail. On T cells, CD8 is the coreceptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the Ig-like domain of CD8α interacts with the α3-domain of the MHC class I molecule. CD8 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and the α chain recruits the tyrosine kinase Lck, which is essential for T cell activation (1).

Specifications