We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Cell Signaling Zscan4 (E9z7b) Rabbit mAb
List Price
$374.71
Your Price
$374.71
Cell Signaling Zscan4 (E9z7b) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-89585S
MFG.PART:
89585S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H |
| Sensitivity | Transfected Only |
| Molecular Weight (kDa) | 60 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | Transfected Only |
| Species Reactivity | Human |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro240 of human ZSCAN4 protein. |
| Background | Zinc finger and SCAN domain-containing protein 4 (ZSCAN4) is a transcription factor that is selectively expressed in a unique subpopulation of embryonic stem (ES) cells. Embryonic development is initially controlled by maternally-deposited transcripts and subsequently by zygotic transcription, following the maternal-to-zygotic transition and zygotic genome activation (ZGA) (1). ZGA occurs at the 2-cell (2C) stage of embryonic development, and ZSCAN4 is a specific marker of this stage for embryo and ES cells (2). ZSCAN4 has been shown to regulate telomere maintenance in mouse ES cells and bind to nucleosomal microsatellite DNA repeats, which are prone to genomic instability in mouse 2C-like cells (3,4). ZSCAN4 expression has also been positively correlated with derepression of heterochromatin in mouse ES cells (5). Additionally, ZSCAN4 was shown to facilitate alterations to the chromatin landscape and promote the cancer stem cell phenotype in head and neck squamous cell carcinoma (6). |
| SKU | CSIG-89585S |
|---|---|
| Featured | No |
| Supplier Part Number | 89585S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |