Cell Signaling Connexin 43 (E7n2r) Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Connexin 43 (E7n2r) Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-89289SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Connexin 43 (E7n2r) Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-89289SF

MFG.PART: 89289SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	39, 41, 43, 44
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #83649
Specificity/Sensitivity	Connexin 43 (E7N2R) XP® Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total connexin 43 protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg374 of human connexin 43 protein.
Background	Connexin 43 (Cx43) is a member of the large family of gap junction proteins. Connexins assemble as a hexamer and are transported to the plasma membrane to create a hemichannel that can associate with hemichannels on nearby cells to create cell-to-cell channels. Clusters of these channels assemble to make gap junctions. Gap junction communication is important in development and regulation of cell growth. Phosphorylation of Cx43 is important in regulating assembly and function of gap junctions (1,2). Ser368 of Cx43 is phosphorylated by protein kinase C (PKC) after activation by phorbol esters, which decreases cell-to-cell communication (3). Src can interact with and phosphorylate Cx43 to alter gap junction communication (4,5).

Specifications