Cell Signaling Phospho-Alpha-Synuclein (Ser129) (D1r1r) Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Phospho-Alpha-Synuclein (Ser129) (D1r1r) Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-87281SF
Price: 884.76 USD

List Price $884.76 Your Price $884.76

Cell Signaling Phospho-Alpha-Synuclein (Ser129) (D1r1r) Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-87281SF

MFG.PART: 87281SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	18
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free. For standard formulation of this product see product #23706.
Specificity/Sensitivity	Phospho-α-Synuclein (Ser129) (D1R1R) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of α-Synuclein protein only when phosphorylated at Ser129. Specificity of nuclear staining is unclear but consistent with previous publications (4).
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser129 of human α-Synuclein protein.
Background	α-Synuclein is a protein of 140-amino acids expressed abundantly in the brain. α-Synuclein is also the main component of pathogenic Lewy bodies and Lewy neurites. Research studies have shown that mutations of the α-Synuclein gene are linked to Parkinsons disease (1).Various research studies have shown that phosphorylation of α-Synuclein at Ser129 is a highly toxic event causing degeneration of dopaminergic neurons associated with Parkinsons disease. This is proposed to occur through increased misfolding, aggregation, and accumulation of α-Synuclein phosphorylated at this site (2). GSK-3β is one of several kinases that has been reported to phosphorylate α-Synuclein at Ser129 (3).

Specifications