Cell Signaling 4-1bb/Cd137/Tnfrsf9 Antibody (Mouse Specific)

Name: Cell Signaling 4-1bb/Cd137/Tnfrsf9 Antibody (Mouse Specific)
SKU: CSIG-85495S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling 4-1bb/Cd137/Tnfrsf9 Antibody (Mouse Specific) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-85495S

MFG.PART: 85495S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	M
Sensitivity	Endogenous
Molecular Weight (kDa)	24-28, 40-50
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	4-1BB/CD137/TNFRSF9 Antibody recognizes endogenous levels of total 4-1BB/CD137/TNFRSF9 protein.
Species Reactivity	Mouse
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu110 of mouse 4-1BB/CD137/TNFRSF9 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	TNFRSF9 is a member of the tumor necrosis factor receptor superfamily (1,2). It is also called 4-1BB or CD137 (1, 2). 4-1BB/CD137/TNFRSF9 is expressed in activated CD4+ and CD8+ T cells, natural killer cells and dendritic cells (2-5). The ligand 4-1BBL/CD137L/TNFSF9 on antigen presenting cells binds to 4-1BB/CD137/TNFRSF9 and costimulates the activation of T cells (5). The binding of agonistic antibodies to 4-1BB/CD137/TNFRSF9 also leads to costimulation for T cell activation (5). Studies have shown the effectiveness of targeting 4-1BB/CD137/TNFRSF9 by its agonistic antibodies in cancer immunotherapy (6).

Specifications