Cell Signaling Cd69 (Fn50) Mouse mAb (Pe-Cy7 Conjugate)

Name: Cell Signaling Cd69 (Fn50) Mouse mAb (Pe-Cy7 Conjugate)
SKU: CSIG-85313S
Price: 360.57 USD

List Price $360.57 Your Price $360.57

Cell Signaling Cd69 (Fn50) Mouse mAb (Pe-Cy7 Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-85313S

MFG.PART: 85313S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	500 µl (100 tests)
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Mouse IgG1 kappa
Application/Dilution	{Flow Cytometry (Live): 1:20}
Storage	Supplied in 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2. This product is stable for 6 months when stored at 4ºC. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	CD69 (FN50) Mouse mAb (PE-Cy7® Conjugate) recognizes endogenous levels of total CD69 protein. This antibody detects an epitope within the extracellular domain.
Species Reactivity	Human
Source/Purification	This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.
Background	CD69, also known as Leu-23, is a type II transmembrane glycoprotein that is expressed on the surface of T cells, B cells, and NK cells (1,2). This phosphorylated disulfide-linked 28 to 32-kDa homodimer is constitutively expressed on a subset of thymocytes and platelets. It also acts as an activation antigen of lymphocytes, NK cells, neutrophils, and eosinophils (1-6). Studies have shown that stimulation of the T cell receptor (TCR) increases the expression of CD69 on the cell surface. The ability to detect the level of CD69 expression after TCR activation makes CD69 an ideal indicator of T cell activation (1). The FN50 antibody is widely used as a marker for T cell activation (7).

Specifications