Cell Signaling Tnfrsf17/Bcma (E6d7b) Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Tnfrsf17/Bcma (E6d7b) Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-84031SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Tnfrsf17/Bcma (E6d7b) Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-84031SF

MFG.PART: 84031SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	18-30
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free. For standard formulation of this product see product #88183.
Specificity/Sensitivity	TNFRSF17/BCMA (E6D7B) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total TNFRSF17/BCMA protein. This antibody displays some non-specific staining of peripheral and CNS tissue when used for IHC-P.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu115 of human TNFRSF17/BCMA protein.
Background	B cell maturation antigen (BCMA/TNFRSF17/CD269) is a transmembrane glycoprotein and member of the TNFR superfamily (1). BCMA expression is largely restricted to the B cell lineage. Pro-survival signaling through this receptor plays a pivotal role in humoral immunity by regulating B cell maturation and plasma cell differentiation upon binding its ligands, BAFF and APRIL (2-6). BCMA is expressed in a number of B cell malignancies and has garnered much attention as a novel therapeutic target for the treatment of multiple myeloma due to its selective and elevated expression on the cell surface of malignant plasma cells (7-10).

Specifications