Cell Signaling Aldh1a2 Antibody

Name: Cell Signaling Aldh1a2 Antibody
SKU: CSIG-83805S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Aldh1a2 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-83805S

MFG.PART: 83805S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M
Sensitivity	Endogenous
Molecular Weight (kDa)	55
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	ALDH1A2 Antibody recognizes endogenous levels of total ALDH1A2 protein. Based on sequence comparisons, the antibody is not predicted to cross-react with ALDH1A1.
Species Reactivity	Human, Mouse
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly350 of human ALDH1A2 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	The aldehyde dehydrogenase family is a large group of enzymes that catalyze the oxidization of aldehydes into carboxylic acids (1). Aldehyde Dehydrogenase 1A2 (ALDH1A2, RALHD2) is among a group of aldehyde dehydrogenases that catalyze the metabolism of retinaldehyde into retinoic acid (RA), which plays a critically important signaling role in animal development (2). Research studies have shown that ALDH1A2 also plays a role postnatally in modulating the effects of RA signaling on immune cell function (3-5). In one example using a genetic mouse model, it was shown that ALDH1A2-dependent RA signaling was a downstream mediator of NOTCH-dependent T cell differentiation (6).

Specifications