Cell Signaling Tmem119 (E3e4t) Mouse mAb (Bsa And Azide Free)

Name: Cell Signaling Tmem119 (E3e4t) Mouse mAb (Bsa And Azide Free)
SKU: CSIG-83308SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Tmem119 (E3e4t) Mouse mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-83308SF

MFG.PART: 83308SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Mouse IgG2a
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free. For standard formulation of this product see product #41134.
Specificity/Sensitivity	TMEM119 (E3E4T) Mouse mAb (BSA and Azide Free) recognizes endogenous levels of total TMEM119 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human TMEM119 protein.
Background	Transmembrane protein 119 (TMEM119) is a cell-surface protein of unknown function, expressed exclusively by the microglia subset of myeloid and neural cells (1). Iba1+ microglia with both ramified and amoeboid morphologies express TMEM119, while Iba1+ macrophages are TMEM119 negative (2). TMEM119 and other homeostatic genes have been shown to be downregulated in disease-associated microglia (DAM). These DAM microglia are conserved in human and mouse and have been identified in Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), and 5XFAD and APP/PS1 mouse models (3,4). This protein’s specificity as a microglia marker has proven itself important for labeling microglia in healthy tissue as well as deciphering them from infiltrating macrophages and other cells types in neurodegenerative disease models (1,2).

Specifications