Cell Signaling G3bp1 (E9g1m) Xp Rabbit mAb (Alexa Fluor 555 Conjugate)

Name: Cell Signaling G3bp1 (E9g1m) Xp Rabbit mAb (Alexa Fluor 555 Conjugate)
SKU: CSIG-83279S
Price: 454.50 USD

List Price $454.50 Your Price $454.50

Cell Signaling G3bp1 (E9g1m) Xp Rabbit mAb (Alexa Fluor 555 Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-83279S

MFG.PART: 83279S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl (50 tests)
Reactivity	H Mk
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Immunofluorescence (Immunocytochemistry): 1:50}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	G3BP1 (E9G1M) XP® Rabbit mAb (Alexa Fluor® 555 Conjugate) recognizes endogenous levels of total G3BP1 protein. This antibody does not cross-react with G3BP2 protein.
Species Reactivity	Human, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val218 of human G3BP1 protein.
Background	Ras GTPase-activating protein-binding protein 1, also known as GAP SH3 domain-binding protein 1 (G3BP1), was identified as a protein that interacts with the SH3 domain of Ras GTPase-activating protein (RasGap) (1). G3BP1 is involved in the regulation of multiple cellular processes, including mRNA decay and inhibition of translation initiation (2). Furthermore, G3BP1 is essential for the assembly of stress granules (SGs) and functions as an SG-nucleating protein (3). Research studies show that arginine demethylation of G3BP1 promotes SG assembly during oxidative stress (4).

Specifications