Cell Signaling Tyrosine Hydroxylase (E2l6m) Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Tyrosine Hydroxylase (E2l6m) Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-81242SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Tyrosine Hydroxylase (E2l6m) Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-81242SF

MFG.PART: 81242SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	55-60
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free. For standard formulation of this product see product #58844.
Specificity/Sensitivity	Tyrosine Hydroxylase (E2L6M) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total tyrosine hydroxylase protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human tyrosine hydroxylase protein.
Background	Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of the neurotransmitter dopamine and other catecholamines. TH functions as a tetramer, with each subunit composed of a regulatory and catalytic domain, and exists in several different isoforms (1,2). This enzyme is required for embryonic development since TH knockout mice die before or at birth (3). Levels of transcription, translation and post-translational modification regulate TH activity. The amino-terminal regulatory domain contains three serine residues: Ser9, Ser31, and Ser40. Phosphorylation at Ser40 by PKA positively regulates the catalytic activity of TH (4-6). Phosphorylation at Ser31 by CDK5 also increases the catalytic activity of TH through stabilization of TH protein levels (7-9).

Specifications