Cell Signaling Cd84 (E4f2n) Rabbit mAb

Name: Cell Signaling Cd84 (E4f2n) Rabbit mAb
SKU: CSIG-80519S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Cd84 (E4f2n) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-80519S

MFG.PART: 80519S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	M
Sensitivity	Endogenous
Molecular Weight (kDa)	45-80
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:200}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	CD84 (E4F2N) Rabbit mAb recognizes endogenous levels of total CD84 protein.
Species Reactivity	Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of mouse CD84 protein.
Background	Cluster of Differentiation 84 (CD84), also known as signaling lymphocytic activation molecule family member 5 (SLAMF5), is a membrane glycoprotein expressed by numerous immune cell types, including hematopoietic progenitor cells, T cells, B cells, NK cells, macrophages, monocytes, dendritic cells, platelets, mast cells, and thymocytes (1-9). CD84 is a homophilic adhesion molecule involved in modulating the activation, differentiation, proliferation, and cytotoxicity of a wide variety of immune cells, and thus is involved in the regulation and interconnection of both the innate and adaptive immune response (6-14). Certain CD84 activities are regulated by the presence or absence of small cytoplasmic adaptor proteins, SH2D1A/SAP and/or SH2D1B/EAT-2 (5,14). Alternate splicing results in multiple transcript variants.

Specifications