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Cell Signaling Fatp2/Slc27a2 (E8f8o) Rabbit mAb
List Price
$342.39
Your Price
$342.39
Cell Signaling Fatp2/Slc27a2 (E8f8o) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-78771S
MFG.PART:
78771S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H M |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 70 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:50} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | FATP2/SLC27A2 (E8F8O) Rabbit mAb recognizes endogenous levels of total FATP2/SLC27A2 protein. This antibody does not cross-react with FATP1/SLC27A1 protein. |
| Species Reactivity | Human, Mouse |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val381 of human FATP2/SLC27A2 protein. |
| Background | Fatty acid transport protein 2 (FATP2), also known as solute carrier family 27 member 2 (SLC27A2), transports long-chain fatty acids into cells at the cell membrane. FATP2/SLC27A2 also functions as a very long-chain acyl-CoA synthetase in the endoplasmic reticulum to activate very long-chain fatty acids (1). Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are pathologically activated neutrophils that accumulate in many diseases. The immunosuppressive activity of PMN-MDSCs is critical in regulating immune responses in cancer. Studies show that FATP2/SLC27A2 expression is upregulated in PMN-MDSCs. FATP2/SLC27A2 mediates the suppressive activity of PMN-MDSCs by increasing the uptake of arachidonic acid and synthesis of prostaglandin E2. In addition, deletion of FATP2/SLC27A2 is shown to abolish the suppressive activity of PMN-MDSCs (2). These results suggest that targeting FATP2/SLC27A2 may increase anti-tumor immunity (2,3). |
| SKU | CSIG-78771S |
|---|---|
| Featured | No |
| Supplier Part Number | 78771S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |