Cell Signaling Cthrc1 (E6w2e) Rabbit mAb

Name: Cell Signaling Cthrc1 (E6w2e) Rabbit mAb
SKU: CSIG-78524S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Cthrc1 (E6w2e) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-78524S

MFG.PART: 78524S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	29
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	CTHRC1 (E6W2E) Rabbit mAb recognizes endogenous levels of total CTHRC1 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala226 of human CTHRC1 protein.
Background	Collagen triple helix repeat containing-1 (CTHRC1) is a secreted glycoprotein involved in wound repair, vascular and bone remodeling, matrix deposition, and migration. CTHRC1 is overexpressed in multiple human cancers, and its expression is associated with increased migration and metastasis, as well as decreased survival (1-3).CTHRC1 expression is regulated through TGF-β/Smad3 signaling, and its effects on migration and invasion are mediated by several signaling pathways, including TGF-β, Wnt, integrin β/FAK, Src/FAK, MEK/ERK, PI3K/AKT/ERK, HIF-1α, and PKC-δ/ERK (3). CTHRC1 protein is elevated in the peripheral blood of Rheumatoid arthritis (RA) patients, and CTHRC1 is thought to be a driver of RA progression (4).

Specifications