Cell Signaling Morc2 Antibody

Name: Cell Signaling Morc2 Antibody
SKU: CSIG-77667S
Price: 359.56 USD

List Price $359.56 Your Price $359.56

Cell Signaling Morc2 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-77667S

MFG.PART: 77667S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	135
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	MORC2 Antibody recognizes endogenous levels of total MORC2 protein.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu681 of human MORC2 protein. Antibodies are purified by peptide affinity chromatography.
Background	Microrchidia family CW-type zinc finger 2 (MORC2) is a protein involved in ATP-dependent chromatin remodeling and DNA repair (1-3). Upon DNA damage, MORC2 dimerizes and is phosphorylated by PAK1. PARP1 can then recruit MORC2 to break sites, where it destabilizes histone-DNA interactions, and recruits DNA repair proteins, such as BRCA1 and Rad51 (4,5). MORC2 is recruited by the HUSH epigenetic silencing complex to sites of heterochromatin (6). MORC2 has also been shown to downregulate important tumor suppressors p21 and ArgBP2 in gastric cancers by recruitment of EZH2 (7-9). Mutations in the MORC2 gene locus have been shown to cause the axonal form of Charcot-Marie-Tooth disease (CMT), a disorder of the motor and sensory neurons of the peripheral nervous system (8-11).

Specifications