Cell Signaling Alad (E8z7y) Rabbit mAb

Name: Cell Signaling Alad (E8z7y) Rabbit mAb
SKU: CSIG-76798S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Alad (E8z7y) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-76798S

MFG.PART: 76798S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	36
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	ALAD (E8Z7Y) Rabbit mAb recognizes endogenous levels of total ALAD protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro46 of human ALAD protein.
Background	Delta-aminolevulinic acid dehydratase (ALAD) catalyzes the second step in heme biosynthesis. ALAD is also an endogenous inhibitor of the 26S proteasome (1). Defects in ALAD cause acute hepatic porphyria, an inherited defect in heme biosynthesis in the liver (2). ALAD activity is inhibited by lead, and defects in ALAD result in sensitivity to lead poisoning (3). Reduced expression of ALAD is associated with poor prognosis in breast cancer patients. Overexpression of ALAD in breast cancer cells negatively regulates proliferation, invasion, and transforming growth factor-β (TGF-β)-mediated epithelial-mesenchymal transition (EMT) (4).

Specifications