Cell Signaling Card14 (E3f8e) Rabbit mAb

Name: Cell Signaling Card14 (E3f8e) Rabbit mAb
SKU: CSIG-76536S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Card14 (E3f8e) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-76536S

MFG.PART: 76536S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	120-140
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	CARD14 (E3F8E) Rabbit mAb recognizes endogenous levels of total CARD14 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn96 of human CARD14 protein.
Background	CARD14 (caspase recruitment domain-containing protein 14) is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, functioning as molecular scaffolds for the assembly of multiprotein complexes (1-3). CARD14 has been shown to regulate BCL10 function, leading to NF-κB activation (1-3). It also induces activation of p38 and JNK MAP kinase pathways via interaction with MALT1 (4). Full-length CARD14, CARD14fl or isoform 1, encodes both an N-terminal CARD domain necessary for NF-kB activation, and a C-terminal tripartite MAGUK domain (PDZ/SH3/GUK). A shorter isoform, CARD14sh, encodes the CARD domain but not the tripartite domain (1,2). Mutations of CARD14 are associated with psoriasis and psoriatic arthritis (2,3).

Specifications