Cell Signaling Cd14 (D7a2t) Rabbit mAb (Ihc Formulated)

Name: Cell Signaling Cd14 (D7a2t) Rabbit mAb (Ihc Formulated)
SKU: CSIG-75181S
Price: 360.57 USD

List Price $360.57 Your Price $360.57

Cell Signaling Cd14 (D7a2t) Rabbit mAb (Ihc Formulated) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-75181S

MFG.PART: 75181S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H Mk
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{IHC Leica Bond: 1:200, Immunohistochemistry (Paraffin): 1:500}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #43878.
Specificity/Sensitivity	CD14 (D7A2T) Rabbit mAb (IHC Formulated) recognizes endogenous levels of total CD14 protein.
Species Reactivity	Human, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro319 of human CD14 protein.
Background	CD14 is a leucine-rich repeat-containing pattern recognition receptor with expression largely restricted to the monocyte/macrophage cell lineage (1). Research studies have shown that CD14 is a bacterial lipopolysaccharide (LPS) binding glycoprotein, expressed as either a GPI-linked membrane protein or a soluble plasma protein (2). LPS induces an upregulation of GPI-linked CD14 expression, which facilitates TLR4 signaling and macrophage activation in response to bacterial infection (3-5).

Specifications