Cell Signaling Asct2 (D7c12) Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Asct2 (D7c12) Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-69974SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Asct2 (D7c12) Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-69974SF

MFG.PART: 69974SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	49, 75
Source/Isotype	Rabbit
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #8057
Specificity/Sensitivity	ASCT2 (D7C12) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total ASCT2 protein.
Species Reactivity	Human, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human ASCT2 protein.
Background	Sodium-dependent neutral amino acid transporter type 2 (ASCT2 or SLC1A5) is a neutral amino acid transporter that regulates the uptake of essential amino acids in conjunction with the SLC7A5 bilateral transporter (1,2). ASCT2 appears to be the major glutamine transporter in hepatoma cells and is thought to provide essential amino acids needed for tumor growth (3). Additional evidence suggests that ASCT2 plays a role in activating mTORC1 signaling and is required to suppress autophagy (4,5). Cell surface ASCT2 serves as a receptor for several mammalian interference retroviruses associated with cases of infectious immunodeficiency; variation in a small region of an extracellular loop (ECL2) may be responsible for species-specific differences in receptor function (6).

Specifications