Cell Signaling Muc1 (Vu4h5) Mouse mAb (Bsa And Azide Free)

Name: Cell Signaling Muc1 (Vu4h5) Mouse mAb (Bsa And Azide Free)
SKU: CSIG-68123SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Muc1 (Vu4h5) Mouse mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-68123SF

MFG.PART: 68123SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	230, 400
Source/Isotype	Mouse IgG1
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #4538
Specificity/Sensitivity	MUC1 (VU4H5) Mouse mAb detects endogenous levels of total MUC1. This antibody does not cross-react with other mucin proteins.
Species Reactivity	Human
Source/Purification	Monoclonal antibody (isotype: IgG1k) is produced by immunizing a BALB/c mouse with MUC1 60 mer tandem repeats (BSA conjugated).
Background	Mucins represent a family of glycoproteins characterized by repeat domains and dense O-glycosylation (1). MUC1 (or mucin 1) is aberrantly overexpressed in most human carcinomas. Increased expression of MUC1 in carcinomas reduces cell-cell and cell-ECM interactions. MUC1 is cleaved proteolytically, and the large ectodomain can remain associated with the small 25 kDa carboxy-terminal domain that contains a transmembrane segment and a 72-residue cytoplasmic tail (1). MUC1 interacts with ErbB family receptors and potentiates ERK1/2 activation (2). MUC1 also interacts with β-catenin, which is regulated by GSK-3β, PKCγ, and Src through phosphorylation at Ser44, Thr41, and Tyr46 of the MUC1 cytoplasmic tail (3-5). Overexpression of MUC1 potentiates transformation (6) and attenuates stress-induced apoptosis through the Akt or p53 pathways (7,8).

Specifications