Cell Signaling Sting (D2p2f) Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Sting (D2p2f) Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-67733SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Sting (D2p2f) Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-67733SF

MFG.PART: 67733SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H M
Sensitivity	Endogenous
Molecular Weight (kDa)	33, 35
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #13647.
Specificity/Sensitivity	STING (D2P2F) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total STING protein.
Species Reactivity	Human, Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro226 of human STING protein.
Background	Stimulator of interferon genes (STING, TMEM173, MITA) is a transmembrane adaptor protein that is a critical component of the cellular innate immune response to pathogenic cytoplasmic DNA (1,2). STING is a ubiquitously expressed protein found predominantly in the ER (1). The enzyme cGAMP synthase (cGAS) produces the second messenger cyclic-GMP-AMP (cGAMP) in response to cytoplasmic DNA (3,4). cGAMP binds and activates STING (3,4). In addition, detection of cytoplasmic DNA by nucleic acid sensors, including DDX41 or IFI16, results in STING activation (5,6). Following activation, STING translocates with TBK1 to perinuclear endosomes (7). The TBK1 kinase phosphorylates and activates interferon regulatory factors (IRFs) and NF-κB, which leads to the induction of type I interferon and other immune response genes (1,2,7).

Specifications