Cell Signaling Pan-Keratin (Ae1/Ae3) Mouse mAb

Name: Cell Signaling Pan-Keratin (Ae1/Ae3) Mouse mAb
SKU: CSIG-67306S
Price: 353.50 USD

List Price $353.50 Your Price $353.50

Cell Signaling Pan-Keratin (Ae1/Ae3) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-67306S

MFG.PART: 67306S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Mouse IgG1
Application/Dilution	{IHC Leica Bond: 1:400 - 1:1600, Immunohistochemistry (Paraffin): 1:50 - 1:200, Immunofluorescence (Immunocytochemistry): 1:100 - 1:400}
Storage	Supplied in a PBS-based buffer with ~1% BSA and less than 0.1% sodium azide. Stable for 6 months when stored at 4°C. Do not aliquot the antibody.
Specificity/Sensitivity	Pan-Keratin (AE1/AE3) Mouse mAb recognizes endogenous levels of acidic and basic subfamilies of keratin proteins. The acidic keratins have molecular weights of 56.5, 55, 51, 50, 50, 48, 46, 45, and 40 kDa. The basic keratins have molecular weights of 65-67, 64, 59, 58, 56, and 52 kDa.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a full-length protein to human epidermal keratins.
Background	Keratins (cytokeratins) are intermediate filament proteins that are mainly expressed in epithelial cells. Keratin heterodimers composed of an acidic keratin (or type I keratin, keratins 9 to 23) and a basic keratin (or type II keratin, keratins 1 to 8) assemble to form filaments (1,2). Keratin isoforms demonstrate tissue- and differentiation-specific profiles that make them useful as research biomarkers (1). Research studies have shown that mutations in keratin genes are associated with skin disorders, liver and pancreatic diseases, and inflammatory intestinal diseases (3-6).

Specifications