Cell Signaling Phospho-Jak1 (Tyr1034/1035)/Jak2 (Tyr1007/1008) (E9y7v) Mouse mAb

Name: Cell Signaling Phospho-Jak1 (Tyr1034/1035)/Jak2 (Tyr1007/1008) (E9y7v) Mouse mAb
SKU: CSIG-66245S
Price: 400.97 USD

List Price $400.97 Your Price $400.97

Cell Signaling Phospho-Jak1 (Tyr1034/1035)/Jak2 (Tyr1007/1008) (E9y7v) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-66245S

MFG.PART: 66245S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M
Sensitivity	Endogenous
Molecular Weight (kDa)	125, 130
Source/Isotype	Mouse IgG2a
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:100}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Phospho-Jak1 (Tyr1034/1035)/Jak2 (Tyr1007/1008) (E9Y7V) Mouse mAb recognizes endogenous levels of Jak2 protein only when phosphorylated at Tyr1007 and Tyr1008 and endogenous levels of Jak1 when phosphorylated at Tyr1034 and Tyr1035. This antibody may cross-react with phospho-Jak3 and phospho-Tyk2.
Species Reactivity	Human, Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr1007/Tyr1008 of human Jak2 protein.
Background	Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors (1). Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide multiple binding sites for signaling proteins. These associated signaling proteins, such as Stats (2), Shc (3), insulin receptor substrates (4), and focal adhesion kinase (FAK) (5), typically contain SH2 or other phospho-tyrosine-binding domains.

Specifications