Cell Signaling Pd-L2 (D6l5a) Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Pd-L2 (D6l5a) Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-64714SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Pd-L2 (D6l5a) Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-64714SF

MFG.PART: 64714SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	M
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #49189
Specificity/Sensitivity	PD-L2 (D6L5A) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total PD-L2 protein. Staining of unknown specificity in mouse ovary has been observed.
Species Reactivity	Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala85 of mouse PD-L2 protein.
Background	Programmed cell death 1 ligand 2 (PD-L2, B7-DC, CD273) is a member of the B7 family of cell surface ligands that regulate T-cell activation and immune responses (1,2). PD-L2 binds the PD-1 transmembrane receptor and inhibits T-cell activation. PD-L2 was discovered following a search for novel B7 protein homologs and was later shown to be expressed by activated dendritic cells, macrophages, and T-cells (1,3). Similar in structure to related B7 family members, PD-L2 protein contains extracellular IgV and IgC2 domains, a transmembrane domain, and a short, cytoplasmic region. Research studies demonstrate that PD-L2 is expressed in several tumor types, including lung cancer, renal cell carcinoma, melanoma, Hodgkins lymphoma and primary mediastinal large B-cell lymphoma (4-7).

Specifications