Cell Signaling Cox10 Antibody

Name: Cell Signaling Cox10 Antibody
SKU: CSIG-62387S
Price: 359.56 USD

List Price $359.56 Your Price $359.56

Cell Signaling Cox10 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-62387S

MFG.PART: 62387S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	49
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	COX10 Antibody recognizes endogenous levels of total COX10 protein.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp31 of human COX10 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	COX10 is an assembly factor for cytochrome c oxidase (COX, also known as complex IV) in the mitochondrial electron transport chain (1,2). Studies show that, when the gene encoding the β2-adrenergic receptor (Adrb2) is deleted, increased oxidative phosphorylation in endothelial cells inhibits angiogenesis. Deletion of Cox10 prevents the metabolic switch to oxidative phosphorylation in endothelial cells deleted of Adrb2, causing angiogenesis and cancer progression (2). In addition, COX10 contributes to T cell quiescence exit and is critical for T cell activation (3).

Specifications