Cell Signaling Bcl-Xl (54h6) Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Bcl-Xl (54h6) Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-61060SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Bcl-Xl (54h6) Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-61060SF

MFG.PART: 61060SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	30
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free. For standard formulation of this product see product #2764.
Specificity/Sensitivity	Bcl-xL (54H6) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total Bcl-xL protein. This antibody does not cross-react with other Bcl-xL proteins.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp61 of human Bcl-xL protein.
Background	Bcl-xL prevents apoptosis through two different mechanisms: heterodimerization with an apoptotic protein inhibits its apoptotic effect (1,2) and formation of mitochondrial outer membrane pores help maintain a normal membrane state under stressful conditions (3). Bcl-xL is phosphorylated by JNK following treatment with microtubule-damaging agents, such as paclitaxel, vinblastine, and nocodazole (4,5).

Specifications