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Cell Signaling Sars-Cov-2 Orf9b Antibody
List Price
$309.06
Your Price
$309.06
Cell Signaling Sars-Cov-2 Orf9b Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-60951S
MFG.PART:
60951S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | Vir |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 10 |
| Source/Isotype | Rabbit |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | SARS-CoV-2 ORF9b Antibody recognizes endogenous levels of total SARS-CoV-2 ORF9b protein. |
| Species Reactivity | Virus |
| Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp66 of SARS-CoV-2 ORF9b protein. Antibodies are purified by peptide affinity chromatography. |
| Background | ORF9b (open reading frame 9b) is one of a variable number of so-called accessory proteins encoded by the genomes of coronaviruses such as SARS-CoV-2, the agent responsible for the COVID-19 global pandemic (1). Research studies have suggested that viral accessory proteins may not contribute directly to viral replication, but rather support viral infection by interfering with host defense mechanisms (2). For example, studies of SARS-CoV-1, the agent responsible for the 2003 SARS epidemic, revealed that SARS-CoV-1 ORF9b contributes to suppression of the host interferon (IFN) response, in part by interfering with key IFN effector proteins on the mitochondrial membrane (3). A conserved mechanism of action has since been described for ORF9b of SARS-CoV-2. Studies have shown that SARS-CoV-2 ORF9b localizes to the host mitochondrial membrane, and physically associates with TOM70, an adaptor protein within the MAVS/TRAF3/TRAF6/TOM70 protein complex on the mitochondrial membrane that promotes IFN signaling in response to viral infection (4,5). |
| SKU | CSIG-60951S |
|---|---|
| Featured | No |
| Supplier Part Number | 60951S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |