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Cell Signaling Rhog (E9b7z) Rabbit mAb
List Price
$342.39
Your Price
$342.39
Cell Signaling Rhog (E9b7z) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-60370S
MFG.PART:
60370S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H M R |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 20 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | RhoG (E9B7Z) Rabbit mAb recognizes endogenous levels of total RhoG protein. This antibody does not cross-react with Rac1 or Cdc42 proteins. |
| Species Reactivity | Human, Mouse, Rat |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala144 of human RhoG protein. |
| Background | Rho family small GTPases, including Rho, Rac and Cdc42, act as molecular switches, regulating processes such as cell migration, adhesion, proliferation, and differentiation. They are activated by guanine nucleotide exchange factors (GEFs), which catalyze the exchange of bound GDP for GTP, and they are inhibited by GTPase activating proteins (GAPs), which catalyze the hydrolysis of GTP to GDP. A third level of regulation is provided by the stoichiometric binding of Rho GDP dissociation inhibitor (RhoGDI) (1).RhoG, a Rho family GTPase similar to Rac1 and Cdc42, regulates actin dynamics and cell migration.RhoG regulates the microtubule-mediated formation of focal adhesions (2), as well as tube formation in vascular endothelial cells (3). RhoG mediates tumor cell invasion in glioblastoma, and regulates paxillin phosphorylation and invadopodia formation in breast cancer cells (4,5). |
| SKU | CSIG-60370S |
|---|---|
| Featured | No |
| Supplier Part Number | 60370S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |