Cell Signaling Cd33 (E6v7h) Rabbit mAb

Name: Cell Signaling Cd33 (E6v7h) Rabbit mAb
SKU: CSIG-60049S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Cd33 (E6v7h) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-60049S

MFG.PART: 60049S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	70-80
Source/Isotype	Rabbit IgG
Application/Dilution	{Immunoprecipitation: 1:100, Immunofluorescence (Immunocytochemistry): 1:400 - 1:1600}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #53391.
Specificity/Sensitivity	CD33 (E6V7H) Rabbit mAb recognizes endogenous levels of total CD33 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human CD33 protein.
Background	CD33, a type I transmembrane protein, is a sialic acid-binding Ig-like lectin (Siglec-3) of the Ig superfamily, and human CD33 binds preferentially to alpha-2, 6-linked sialic acid. Upon binding to its ligands CD33 transduces an inhibitory signaling through the immunoreceptor tyrosine-based inhibitory motif (ITIM) in its intracellular domain, inhibiting cellular function such as phagocytosis. In addition, CD33 is also involved in other processes, such as adhesion (1-3). Due to its exclusive expression on hematopoietic cells, particularly the myeloid lineage and their progenitors, CD33 has been actively pursued as a therapeutic target against acute myeloid leukemia (AML) (4,5). CD33 may also be involved in Alzheimer’s Disease (6-8).

Specifications