Cell Signaling Cdca5 Antibody

Name: Cell Signaling Cdca5 Antibody
SKU: CSIG-58507S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Cdca5 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-58507S

MFG.PART: 58507S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	35
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	CDCA5 Antibody recognizes endogenous levels of total CDCA5 protein. In some cell lines, this antibody detects a band of unknown origin at approximately 20 kDa.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Phe247 of human CDCA5 protein. Antibodies are purified by peptide affinity chromatography.
Background	Cohesin is a ring-shaped multiprotein complex that functions in sister chromatid cohesion and in establishing higher order chromosome structure. The cohesin complex regulates chromosome segregation, DNA repair, and transcription (1,2).CDCA5 (also known as Sororin) stabilizes the cohesin complex on DNA through inhibition of the cohesion antagonist WAPL (3). CDCA5 promotes cell proliferation and inhibits apoptosis through the AKT signaling pathway in hepatocellular carcinoma (HCC) cells (4). Overexpression of CDCA5 indicates poor prognosis in HCC (5-7).

Specifications