Cell Signaling Fbxo7 (D8l4e) Rabbit mAb

Name: Cell Signaling Fbxo7 (D8l4e) Rabbit mAb
SKU: CSIG-57981S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Fbxo7 (D8l4e) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-57981S

MFG.PART: 57981S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M
Sensitivity	Endogenous
Molecular Weight (kDa)	65-72
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	FBXO7 (D8L4E) Rabbit mAb recognizes endogenous levels of total FBXO7 protein. FBXO7 (D8L4E) Rabbit mAb detects two bands bands in human cerebellum, consistent with multiple FBXO7 isoforms generated by alternative splicing.
Species Reactivity	Human, Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the N-terminus of human FBXO7 protein.
Background	F-box only protein 7 (FBXO7) is the substrate recognition component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. This complex mediates ubiquitination and degradation of targeted proteins. Several “PARK” chromosomal loci have been associated with monogeneic forms of PD, including PARK15 (1). The associated allele for PARK15 is FBXO7, which encodes the FBXO7 protein. Mutations in FBXO7 cause early-onset autosomal recessive PD, and alterations in FBXO7 normal function, e.g. the protein degradation process, may contribute to PD etiology (2, 3). Additionally, expression of specific FBXO7 isoforms generated by alternative splicing is linked with PD (4).

Specifications