Cell Signaling Myelin Protein Zero Antibody

Name: Cell Signaling Myelin Protein Zero Antibody
SKU: CSIG-57518S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Myelin Protein Zero Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-57518S

MFG.PART: 57518S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	28
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunofluorescence (Frozen): 1:1600, Immunofluorescence (Immunocytochemistry): 1:50 - 1:200}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Myelin Protein Zero Antibody recognizes endogenous levels of total Myelin Protein Zero protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val218 of mouse Myelin Protein Zero protein. Antibodies are purified by peptide affinity chromatography.
Background	Myelin Protein Zero (MPZ, myelin P0) is a single pass membrane glycoprotein member of the IgG superfamily (1,2). MPZ is the most abundant myelin protein in the peripheral nervous system and acts as a major structural component of the peripheral myelin sheath (2,3). It has been shown that MPZ is necessary for normal myelin spiraling, compaction, and maintenance, with disruption of the MPZ gene leading to hypomyelination and degradation of associated axons (4). Mutations in the MPZ gene have been associated with demyelinating peripheral neuropathies including Charcot-Marie-Tooth neuropathy type 1B (CMT1B), Dejerine–Sottas syndrome (DSS), and congenital hypomyelination (CH) (5,6).

Specifications