Cell Signaling Bip (C50b12) Rabbit mAb (Alexa Fluor 647 Conjugate)

Name: Cell Signaling Bip (C50b12) Rabbit mAb (Alexa Fluor 647 Conjugate)
SKU: CSIG-57163S
Price: 454.50 USD

List Price $454.50 Your Price $454.50

Cell Signaling Bip (C50b12) Rabbit mAb (Alexa Fluor 647 Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-57163S

MFG.PART: 57163S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl (50 tests)
Reactivity	H M
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Flow Cytometry (Fixed/Permeabilized): 1:50}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	BiP (C50B12) Rabbit mAb (Alexa Fluor® 647 Conjugate) detects endogenous levels of total BiP protein.
Species Reactivity	Human, Mouse
Source/Purification	BiP (C50B12) Rabbit mAb (Alexa Fluor® 647 Conjugate) is produced by immunizing rabbits with a synthetic peptide corresponding to residues surrounding Gly584 of human BiP.
Background	Secretory and transmembrane proteins are synthesized on polysomes and translocated into the endoplasmic reticulum (ER). Inside the ER, these proteins are often modified by disulfide bond formation, amino-linked glycosylation and folding. To help proteins fold properly, the ER contains a pool of molecular chaperones including BiP. BiP was identified as an immunoglobulin heavy chain binding protein in pre-B cells (1,2). It was also found to be induced at the protein level by glucose starvation (3). When protein folding is disturbed inside ER, BiP synthesis is increased. Subsequently, BiP binds to misfolded proteins to prevent them from forming aggregates and assists in proper refolding (4).

Specifications