Cell Signaling Apom (8f12) Mouse mAb

Name: Cell Signaling Apom (8f12) Mouse mAb
SKU: CSIG-5709S
Price: 339.36 USD

List Price $339.36 Your Price $339.36

Cell Signaling Apom (8f12) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-5709S

MFG.PART: 5709S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	21, 25
Source/Isotype	Mouse IgG2a
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	ApoM (8F12) Mouse mAb recognizes endogenous levels of both unglycosylated and glycosylated ApoM protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a purified recombinant fragment of human ApoM protein.
Background	Apolipoproteins are plasma lipoproteins that function as transporters of lipids and cholesterol in the circulatory system. Chylomicrons are a fundamental class of apolipoproteins containing very low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) (1,2).Apolipoprotein M (ApoM) is a novel membrane bound apolipoprotein involved in lipid transport. ApoM primarily interacts with HDL and regulates its metabolism (3). It is highly expressed in hepatocytes and kidney proximal tubule cells. Recently, ApoM was shown to act as a vasculoprotective constituent of HDL by delivering S1P to the S1P receptor on endothelial cells (4). SNPs of ApoM have been associated with type 2 diabetes (5).

Specifications