Cell Signaling Fnip1 Antibody

Name: Cell Signaling Fnip1 Antibody
SKU: CSIG-56832S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Fnip1 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-56832S

MFG.PART: 56832S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	150
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	FNIP1 Antibody recognizes endogenous levels of total FNIP1 protein. A faint band detected at 130 kDa is predicted to be isoform 3.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys785 of human FNIP1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	FNIP1 and FNIP2 were identified as proteins interacting with tumor suppressor folliculin (FLCN) (1-3). FNIP1 and FNIP2 directly associate with AMPK, which indicates that they play roles in the energy and nutrient sensing pathways (1,2). Further studies show that the FLCN/FNIP2 complex functions as a GTPase-activating protein for Rag GTPase C and Rag GTPase D (4). The FLCN/FNIP2 complex thus promotes binding of mTORC1 to Rag heterodimers, leading to mTORC1 activation (4). In addition, along with FLCN, both FNIP1 and FNIP2 contribute to kidney tumor suppression (5).

Specifications