Cell Signaling Notch2 (D76a6) Xp® Rabbit mAb (Alexa Fluor® 555 Conjugate)

Name: Cell Signaling Notch2 (D76a6) Xp® Rabbit mAb (Alexa Fluor® 555 Conjugate)
SKU: CSIG-56679S
Price: 454.50 USD

List Price $454.50 Your Price $454.50

Cell Signaling Notch2 (D76a6) Xp® Rabbit mAb (Alexa Fluor® 555 Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-56679S

MFG.PART: 56679S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl (50 tests)
Reactivity	H M R
Sensitivity	Endogenous
Source/Isotype	Rabbit
Application/Dilution	{Immunofluorescence (Immunocytochemistry): 1:50 - 1:200, Flow Cytometry (Fixed/Permeabilized): 1:50}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	Notch2 (D76A6) XP® Rabbit mAb (Alexa Fluor® 555 Conjugate) recognizes endogenous levels of total Notch2 protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala2378 of human Notch2 protein.
Background	Notch proteins (Notch1-4) are a family of transmembrane receptors that play important roles in development and the determination of cell fate (1). Mature Notch receptors are processed and assembled as heterodimeric proteins, with each dimer comprised of a large extracellular ligand-binding domain, a single-pass transmembrane domain, and a smaller cytoplasmic subunit (Notch intracellular domain, NICD) (2). Binding of Notch receptors to ligands of the Delta-Serrate-Lag2 (DSL) family triggers heterodimer dissociation, exposing the receptors to proteolytic cleavages; these result in release of the NICD, which translocates to the nucleus and activates transcription of downstream target genes (3,4).

Specifications